Cellular Aging: Telomeres & Telomerase, Sirtuins.
A series of video tutorials discussing the topics for undergraduates in Pathology
In this tutorial , i have discussed Cellular Aging
Changes that contribute to cellular aging
The human body is programmed to self-destruct as we age. But the speed at which this happens is entirely up to us. Studies have proven this a fact, time and time again. Unfortunately, I can’t make you 19 again but I certainly can show you how to reverse the aging process drastically with this free audiobook.
There is good evidence that aging-induced alterations in cells are an important component of the aging of the organism
Cellular aging is the result of a progressive decrease in cellular function and viability
caused by genetic abnormalities &
the accumulation of cellular and molecular damage due to the effects of exposure to exogenous influences
Repetitive DNA sequences at the ends of all human chromosomes
They contain thousands of repeats of the six-nucleotide sequence, TTAGGG
In humans there are 46 chromosomes and thus 92 telomeres (one at each end)
They protect the chromosomes.
They separate one chromosome from another in the DNA sequence
Without telomeres, the ends of the chromosomes would be FUSED leading to massive genomic instability.
Telomeres are also thought to be the “clock” that regulates how many times an individual cell can divide.
Telomeric sequences shorten each time the DNA replicates.
Once the telomere shrinks to a certain level, the cell can no longer divide. Its metabolism slows down, it ages, and dies.
Healthy human cells are MORTAL because they can divide only a finite number of times, growing older each time they divide.
Thus cells in an elderly person are much older than cells in an infant.
Telomerase (TEE-LOM-ER-ACE) is a ribonucleoprotein enzyme complex (a cellular reverse transcriptase) that has been referred to as a cellular IMMORTALIZING enzyme.
It stabilizes telomere length by adding (TTAGGG) repeats onto the telomeric ends of the chromosomes, thus compensating for the erosion of telomeres that occurs in its absence.
Family of NAD dependent protein deacetylaces.
Promotes expression of several genes whose products increase longevity
Inhibit metabolic activity, reduce apoptosis, decrease the effects of free radicals, they activate DNA repair enzymes,
Please watch: “WARBURG EFFECT: Hallmark of CANCER. What, Why & How?”